TCUP Qualifying Conditions

Texas now recognizes 14+ qualifying conditions for medical cannabis, from the original epilepsy-only law to the 2025 addition of chronic pain — the single condition expected to transform the program.

Last verified: April 2026

Complete Qualifying Conditions

The following conditions are authorized under Tex. Occ. Code §169.003 as amended through HB 46 (2025):

Condition Added By Year
Epilepsy & seizure disordersSB 339 / HB 37032015 / 2019
Multiple sclerosisHB 37032019
SpasticityHB 37032019
ALS (Lou Gehrig’s disease)HB 37032019
AutismHB 37032019
Incurable neurodegenerative diseasesHB 37032019
Cancer (all forms)HB 15352021
PTSDHB 15352021
Chronic pain (90+ days)HB 462025
Crohn’s disease / IBDHB 462025
Traumatic brain injuryHB 462025
Degenerative disc diseaseHB 462025
Terminal illnessHB 462025
Hospice / palliative careHB 462025

How the List Grew: Bill by Bill

SB 339 (2015) — Epilepsy Only

The original Texas Compassionate Use Act authorized low-THC cannabis exclusively for patients with intractable epilepsy — seizure disorders that had not responded to at least two conventional treatments. Two board-certified neurologists had to independently concur. The program was designed to be as narrow as politically possible in a conservative legislature.

HB 3703 (2019) — Neurological Conditions

Rep. Stephanie Klick's expansion added six condition categories:

  • Multiple sclerosis
  • Spasticity (from any cause)
  • ALS (Lou Gehrig's disease)
  • Autism
  • Incurable neurodegenerative diseases (defined by DSHS rule)
  • Expanded epilepsy to all seizure disorders

The two-neurologist concurrence requirement was dropped, allowing a single physician to prescribe.

HB 1535 (2021) — Cancer & PTSD

Added all forms of cancer and post-traumatic stress disorder (PTSD). These two conditions drove the most dramatic enrollment surge in TCUP history — from roughly 6,000 patients to over 77,000 by early 2024. PTSD alone accounts for a significant share of current patients.

HB 46 (2025) — The Chronic Pain Expansion

Rep. Ken King's landmark bill added six new condition categories:

  • Chronic pain — defined as continuous or intermittent severe pain lasting 90 or more days
  • Crohn's disease and inflammatory bowel disease
  • Traumatic brain injury (TBI)
  • Degenerative disc disease
  • Terminal illness
  • Hospice and palliative care patients
Chronic Pain Changes Everything

Chronic pain is the most commonly reported medical condition in Texas, affecting millions of residents. Its addition as a qualifying condition could double or triple TCUP enrollment over the next two years. It is the single reason MPP now classifies Texas as having a "comprehensive" medical program.

Neurodegenerative Diseases: The DSHS Definition

The "incurable neurodegenerative diseases" category added in 2019 is defined by DSHS rule at 25 Tex. Admin. Code §1.61. The rule includes but is not limited to:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
  • Dementia with Lewy bodies
  • Frontotemporal degeneration
  • Progressive supranuclear palsy
  • Corticobasal degeneration
  • Motor neuron diseases (beyond ALS)

The list is non-exhaustive — physicians may prescribe for other neurodegenerative conditions that meet the statutory definition of "incurable."

What Does NOT Qualify

Despite the 2025 expansion, several conditions that qualify in other states' programs remain excluded from TCUP:

  • Anxiety disorders (unless secondary to PTSD or another qualifying condition)
  • Depression
  • Insomnia (unless caused by chronic pain or PTSD)
  • Glaucoma
  • HIV/AIDS
  • Migraines (may qualify under chronic pain if the 90-day threshold is met)

Texas does not have a broad "physician discretion" or "comparable conditions" category like Florida or Oklahoma. Each qualifying condition must be specifically enumerated in statute.

How to Get Started

If you have a qualifying condition, the next step is finding a CURT-registered physician who can evaluate you and enter a prescription into the state registry. See our step-by-step enrollment guide for the complete process.